How to Detect Endotoxin on Implanted Medical Apparatus and Instruments


Biocompatibility is a key criterion for implanted medical apparatus and instruments. According to WIKIPEDIA, biocompatibility is related to the behavior of biomaterials in various context. The term refers to the ability of a material to perform with an appropriate host response in a specific situation. The ambiguity of the term reflects the ongoing development of insights into how biomaterials interact with the human body and eventually how those interactions determine the success of a medical device. And endotoxin detection is an important part of biocompatibility.

This article will briefly introduce how to detect endotoxin in implanted medical apparatus and instruments.

1) Eliminate potential ectogenous endotoxin on glass instruments, etc.. Bake glass instruments in electrically heated drying oven with temperature of higher than 250for more than 30 minutes.

2) Prepare sample solution. Put implanted medical apparatus and instruments in Water for BET to extract related medium.

3) Do test for confirmation of labeled lysate sensitivity. This test should be done when a new batch of lysate is used or when there is any change in the test conditions thay may affect the outcome of the test.

4) Develop test for interfering factors to check whether there are interfering factors existing in the sample solution.

5) Do endotoxin detection assay with BIOENDO Lyophilized Amebocyte Lysate (TAL reagent) when the test for confirmation of labeled lysate sensitivity is successful and confirm there is no interfering factor or eliminate interfering influence.

You could contact us via if you want to discuss detailed operation with us. We, Bioendo, have been dedicating to endotoxin and beta-glucan assay since 1978. We are the expert of endotoxin detection and offer overall endotoxin detection solutions for industries involving pyrogen test. All items needed to endotoxin detection like Lyophilized Amebocyte Lysate (TAL reagent), Water for BET, CSE, dry heat incubator, etc. could be found in our company. We offer one-stop service for you to detect endotoxin.

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