New Products
  • X Water Purification System supplier
    Nymph X Water Purification System

    Multi-function; Space Saving; Great Adaptability to Water Source; Easy Operation; Produce Pure Water or Ultrapure Water with Stable and Eligible Quality.

  • Pyrogen-free Centrifuge Tube supplier
    Pyrogen-free Centrifuge Tube

    Pyrogen-free Centrifuge Tubes are widely used when culture cells.

  • USP Standard Gel Clot TAL
    Gel Clot Lyophilized Amebocyte Lysate Single Test in Vial

    Gel Clot Lyophilized Amebocyte Lysate Single Test in Vial contains 0.2 endotoxin-specific Amebocyte Lysate which includes beta-glucan inhibitor in the formulation and will not react to beta-glucan. Furthermore, sample could be added to the vial directly. This means you don’t need to dilute Amebocyte Lysate at first, and could decide how many vials use each time to avoid waste.

  • Gel Clot TAL Multiple Test
    Gel Clot Lyophilized Amebocyte Lysate Multi-test Vial

    Gel Clot Lyophilized Amebocyte Lysate (LAL/TAL) Multi-test Vial is especially suitable for endotoxin detection in large amounts. Bioendo’s LAL/TAL reagent features strong resistance to interference and strong improvement for heat stability.

  • Endotoxin Assay
    Endotoxin Assay Kit for Water and Dialysate (Gel Clot Assay)

    Endotoxin Assay Kit for Water and Dialysate (Gel Clot Assay) assays the endotoxin in water or dialysate by using gel clot technique. Relating operation conforms to USP & EP. Endotoxin-specific Amebocyte Lysate is included by this kit, which will well avoid false positive reaction with Fungi (1,3)-β-D-glucan.

  • GC Endotoxin Test Kit
    Bioendo GC Endotoxin Test Kit (Gel Clot Assay)

    Bioendo GC Endotoxin Test Kit (Gel Clot Assay) includes Amebocyte Lysate, CSE and Water for BET. This will well avoid the mismatching between Amebocyte Lysate and CSE. The Kit is especially suitable for you when you need to do lots of endotoxin detection. Customized gel-clot endotoxin assay kit is also available upon your demand.

What Blue Blood of Horseshoe Crab Can Do

2019-07-19

Horseshoe crab, a harmless and primitive sea creature, plays an important role in nature, that they could be the food for turtles and sharks as well as shorebirds. As functions of its blue blood were found, horseshoe crab also becomes a new life-saving tool.

In 1970s, scientists found that the blue blood of horseshoe crab would clot when they were exposed to E. coli bacteria. It is because the amebocyte in the blue blood of horseshoe crab could react with endotoxins, toxic substances released by E. coli and other gram-negative bacteria which could produce severe symptoms in exposed humans such as fever or hemorrhagic stroke.

Why the blue blood of horseshoe crab has such functions? It may be the results of evolution. The living environment of horseshoe crab is full of bacteria, and horseshoe crab faces the constant threat of infection. The amebocyte in the blue blood of horseshoe crab pay a key role in fighting off infection, that because of the amebocyte, its blue blood could immediately bind and clot around fungi, viruses and bacterial endotoxins. It is the immune system of horseshoe crab that actually make the horseshoe crab’s blood useful to our biomedical industry.

Due to its binding and clotting ability, blue blood of horseshoe crab is used to produce limulus amebocyte lysate, a kind of lyophilized amebocyte lysate. And products produced with the amebocyte from horseshoe crab under different methodologies are developed. At present, there are three technique used to detect bacterial endotoxin by employing lyophilized amebocyte lyate, i.e. gel-clot technique, turbidimetric technique and chromogenic technique. Xiamen Bioendo Technology Co., Ltd. manufacturers lyophilized amebocyte lysate with these three techniques.

Xiamen Bioendo Technology Co., Ltd.

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