New Products
  • X Water Purification System supplier
    Nymph X Water Purification System

    Multi-function; Space Saving; Great Adaptability to Water Source; Easy Operation; Produce Pure Water or Ultrapure Water with Stable and Eligible Quality.

  • Pyrogen-free Centrifuge Tube supplier
    Pyrogen-free Centrifuge Tube

    Pyrogen-free Centrifuge Tubes are widely used when culture cells.

  • USP Standard Gel Clot TAL
    Gel Clot Lyophilized Amebocyte Lysate Single Test in Vial

    Gel Clot Lyophilized Amebocyte Lysate Single Test in Vial contains 0.2 endotoxin-specific Amebocyte Lysate which includes beta-glucan inhibitor in the formulation and will not react to beta-glucan. Furthermore, sample could be added to the vial directly. This means you don’t need to dilute Amebocyte Lysate at first, and could decide how many vials use each time to avoid waste.

  • Gel Clot TAL Multiple Test
    Gel Clot Lyophilized Amebocyte Lysate Multi-test Vial

    Gel Clot Lyophilized Amebocyte Lysate (LAL/TAL) Multi-test Vial is especially suitable for endotoxin detection in large amounts. Bioendo’s LAL/TAL reagent features strong resistance to interference and strong improvement for heat stability.

  • Endotoxin Assay
    Endotoxin Assay Kit for Water and Dialysate (Gel Clot Assay)

    Endotoxin Assay Kit for Water and Dialysate (Gel Clot Assay) assays the endotoxin in water or dialysate by using gel clot technique. Relating operation conforms to USP & EP. Endotoxin-specific Amebocyte Lysate is included by this kit, which will well avoid false positive reaction with Fungi (1,3)-β-D-glucan.

  • GC Endotoxin Test Kit
    Bioendo GC Endotoxin Test Kit (Gel Clot Assay)

    Bioendo GC Endotoxin Test Kit (Gel Clot Assay) includes Amebocyte Lysate, CSE and Water for BET. This will well avoid the mismatching between Amebocyte Lysate and CSE. The Kit is especially suitable for you when you need to do lots of endotoxin detection. Customized gel-clot endotoxin assay kit is also available upon your demand.

What Is Endotoxin

2019-07-05

Endotoxins are small bacterially-derived hydrophobic lipopolysaccharides (LPS) molecules locating in the outer cell membrane of gram-negative bacteria. Endotoxins consist of a core polysaccharide chain, O-specific polysaccharide side chains (O-antigen) and a lipid compenent, Lipid A, which is responsible for the toxic effects. Bacteria shed endotoxin in large amounts upon cell death and when they are actively growing and dividing. A single Escherichia coli contains about 2 million LPS molecules per cell.

Endotoxin can easily contaminate labwares, and its presence can significantly impart both in vitro and in vivo experiments. And for parenteral products, parenteral products contaminated with endotoxins including LPS can lead to the development of fever, induction of inflammatory response, shock, organ failure and death in human. For dialysis products, LPS can be transferred through membrane with large pore size by back-filtration from the dialysis fluid to the blood, inflammatory problems may be caused accordingly.

Endotoxin is detected by the Lyophilized Amebocyte Lysate (LAL). Bioendo has been dedicated to researching, developing and producing LAL reagent for more than four decades. Our products cover all techniques employed to detect endotoxin, which are gel-clot technique, turbidimetric technique, and chromogenic technique.

Xiamen Bioendo Technology Co., Ltd.

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