New Products
  • X Water Purification System supplier
    Nymph X Water Purification System

    Multi-function; Space Saving; Great Adaptability to Water Source; Easy Operation; Produce Pure Water or Ultrapure Water with Stable and Eligible Quality.

  • Pyrogen-free Centrifuge Tube supplier
    Pyrogen-free Centrifuge Tube

    Pyrogen-free Centrifuge Tubes are widely used when culture cells.

  • USP Standard Gel Clot TAL
    USP Standard Gel Clot TAL in Test Tubes

    USP Standard Gel Clot Lyophilized Amebocyte Lysate in Test Tubes is the TAL reagent sealed under vacuum condition in a standard TAL reaction tube. Users add 0.2ml sample to dissolve the TAL reagent and do the test in a single step.

  • Gel Clot TAL Multiple Test
    Gel Clot LAL Reagent multi-test vial

    This is the most commonly used In Vitro method of endotoxin detection. The Gel Clot LAL Reagent multiple-test vial is simple and do not require an expensive instrument. 

  • Endotoxin Assay
    Endotoxin Assay Kit for Water and Dialysate (Gel Clot Assay)

    We supply Endotoxin Assay Kit for dialysis water and dialysate in gel clot method, kinetic turbidimetric method. The kits contain Control Standard Endotoxin, LAL reagent water and pyrogen-free sample bottles.

  • GC Endotoxin Test Kit
    Bioendo GC Endotoxin Test Kit (Gel Clot Assay)

    Bioendo GC Endotoxin Test Kit (Gel Clot Assay) combines Gel Clot TAL reagent and Control Standard Endotoxin in a kit, avoid the mismatched of TAL reagent and CSE.

What Is Endotoxin

2019-07-05

Endotoxins are small bacterially-derived hydrophobic lipopolysaccharides (LPS) molecules locating in the outer cell membrane of gram-negative bacteria. Endotoxins consist of a core polysaccharide chain, O-specific polysaccharide side chains (O-antigen) and a lipid compenent, Lipid A, which is responsible for the toxic effects. Bacteria shed endotoxin in large amounts upon cell death and when they are actively growing and dividing. A single Escherichia coli contains about 2 million LPS molecules per cell.

Endotoxin can easily contaminate labwares, and its presence can significantly impart both in vitro and in vivo experiments. And for parenteral products, parenteral products contaminated with endotoxins including LPS can lead to the development of fever, induction of inflammatory response, shock, organ failure and death in human. For dialysis products, LPS can be transferred through membrane with large pore size by back-filtration from the dialysis fluid to the blood, inflammatory problems may be caused accordingly.

Endotoxin is detected by the Lyophilized Amebocyte Lysate (LAL). Bioendo has been dedicated to researching, developing and producing LAL reagent for more than four decades. Our products cover all techniques employed to detect endotoxin, which are gel-clot technique, turbidimetric technique, and chromogenic technique.

Xiamen Bioendo Technology Co., Ltd.

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